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Abstract

bnt 162b 2, chadox 1ncov 19, coronavac, tozinameran, vaxzevria, adolescent, adult, Brazil, case control study, child, childhood mortality, comorbidity, controlled study, coronavirus disease 2019, data analysis, data base, disease surveillance, groups by age, human, immunization, information processing, Letter, logistic regression analysis, major clinical study, outcome assessment, risk assessment, risk reduction, SARS-CoV-2 Omicron, vaccination

Significance Statement:

Association of Prior COVID-19 Vaccination with SARS-CoV-2 Infection and Death in Children and Young Persons during the Omicron Variant Period in Brazil

Oliveira E.A., Oliveira M.C.L., Simões E Silva A.C., Colosimo E.A., Mak R.H., Pinhati C.C., Martelli H., Jr

This study provides essential insights into the effectiveness of COVID-19 vaccines in children and young individuals during the Omicron variant period in Brazil. Analyzing data from nationwide information surveillance systems, it highlights the variable effectiveness of different vaccine regimens against symptomatic Omicron infection and COVID-19–related death across various age groups. Notably, while the overall effectiveness against symptomatic infection was relatively low, significant protection against COVID-19–related death, especially after the booster dose, was observed. This study's findings are crucial for understanding vaccine performance in young populations, guiding public health strategies and vaccination campaigns.

JAMA Pediatrics

2023

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